verezdoВестник репродуктивного здоровьяBulletin of Reproductive Health2075-65692310-421XEndocrinology Research Centre (Moscow)10.14341/brh12762verezdo-12762Research ArticleНАУЧНЫЕ ОБЗОРЫREVIEWSОсобенности синдрома гипогонадизма у мужчин с ожирениемFeatures of hypogonadism in men with obesityhttps://orcid.org/0009-0009-1348-161XМорозоваЕ. В.MorozovaE. V.

Морозова Елена Валерьевна

117036, Москва, ул. Дм. Ульянова, д. 11 

Elena V. Morozova, MD

11 Dm. Ulyanova street, 117036 Moscow

elenafedoseeva08@gmail.comhttps://orcid.org/0000-0002-5386-4289РоживановР. В.RozhivanovR. V.

Роживанов Роман Викторович, д.м.н.

 

Roman V. Rozhivanov, MD, PhD

Moscow

rrozhivanov@mail.ruhttps://orcid.org/0000-0002-4195-7234РоживановаЕ. Р.RozhivanovaE. R.

Роживанова Екатерина Романовна 

Ekaterina R. Rozhivanova, MD

Moscow

erozhivanova@mail.ruhttps://orcid.org/0009-0006-6107-4494ГайдайчукК. Е.GaidaichukK. E.

Гайдайчук Константин Евгеньевич 

Konstantin E. Gaidaichuk, MD

Moscow

https://orcid.org/0000-0001-8425-0020АндрееваЕ. Н.AndreevaE. N.

Андреева Елена Николаевна, д.м.н., профессор 

Elena N. Andreeva, MD, PhD, Professor

Moscow

endogin@mail.ruhttps://orcid.org/0000-0002-5634-7877МельниченкоГ. А.Mel’nichenkoG. A.

Мельниченко Галина Афанасьевна, д.м.н., профессор, академик РАН  

Galina A. Mel’nichenko, MD, PhD, Professor

Moscow

teofrast2000@mail.ruhttps://orcid.org/0000-0002-9717-9742МокрышеваН. Г.MokryshevaN. G.

Мокрышева Наталья Георгиевна, д.м.н., профессор, член-корр. РАН 

Natalya G. Mokrysheva, MD, PhD, Professor

Moscow

ГНЦ РФ ФГБУ «Национальный медицинский исследовательский центр эндокринологии имени академика И.И. Дедова»РоссияEndocrinology Research CentreRussian FederationГНЦ РФ ФГБУ «Национальный медицинский исследовательский центр эндокринологии имени академика И.И. Дедова»; Российский университет медициныRussian FederationEndocrinology Research Centre; Russian University of MedicineRussian Federation202515072025423136Copyright © Морозова Е.В., Роживанов Р.В., Роживанова Е.Р., Гайдайчук К.Е., Андреева Е.Н., Мельниченко Г.А., Мокрышева Н.Г., 20252025Морозова Е.В., Роживанов Р.В., Роживанова Е.Р., Гайдайчук К.Е., Андреева Е.Н., Мельниченко Г.А., Мокрышева Н.Г.Morozova E.V., Rozhivanov R.V., Rozhivanova E.R., Gaidaichuk K.E., Andreeva E.N., Mel’nichenko G.A., Mokrysheva N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vrz-endojournals.ru/jour/article/view/12762

Во многих эпидемиологических исследованиях обнаружена взаимосвязь между выработкой тестостерона и ожирением. Особенностью ожирения у мужчин является отложение жировой ткани преимущественно в области живота, то есть абдоминальный характер, что приводит к изменению метаболизма половых гормонов. В основе этого лежит двунаправленная взаимосвязь между ожирением и низким уровнем тестостерона через ароматизацию андрогенов, лептинорезистентность, депонирование тестостерона, а также воздействие других коморбидных факторов. В последние годы отмечается повышенный интерес к этой проблеме, и уже накоплены данные, подтверждающие связь между ожирением и снижением уровня тестостерона у мужчин, которые представлены в публикуемом обзоре. При этом снижение жировой массы тела можно рассматривать как подход к коррекции гипогонадизма, ассоциированного с метаболическими нарушениями, так как гипогонадизм, который развивается на фоне метаболических нарушений, является потенциально обратимым.

The relationship between testosterone production and obesity has been found in numerous epidemiological studies. The main feature of obesity in males lies in the fact that it is abdominal obesity, i.e. deposition of adipose tissue mainly in the abdominal area, which has the consequence of affecting sex hormones metabolism. Androgen aromatization, leptin resistance, testosterone deposition, and the influence of other comorbid factors all contribute to the formation of bidirectional relationship between obesity and low testosterone levels. The increased interest in this problem has been observed in recent years, and there is data confirming the link between excess body weight and decreased testosterone levels in males. This latter data is presented in this published review. Meanwhile, reduction of body fat mass can be considered as a proposed approach to correcting hypogonadism associated with metabolic disorders, since hypogonadism in males with metabolic disorders is potentially reversible.

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The authors declare that there are no conflicts of interest present.