verezdoВестник репродуктивного здоровьяBulletin of Reproductive Health2075-65692310-421XEndocrinology Research Centre (Moscow)10.14341/brh12775verezdo-12775Research ArticleРЕДАКЦИОННЫЕ СТАТЬИEDITORIALSВозможности негормональной терапии в коррекции проявлений климактерического синдромаPossibilities of non-hormonal therapy in the correction of manifestations of climacteric syndromehttps://orcid.org/0000-0001-8425-0020АндрееваЕ. Н.AndreevaE. N.

Андреева Елена Николаевна - д.м.н., профессор.

Москва

Elena N. Andreeva - MD, PhD, professor.

Moscow

endogin@mail.ruhttps://orcid.org/0000-0003-0696-5367АбсатароваЮ. С.AbsatarovaYu. S.

Абсатарова Юлия Сергеевна - к.м.н.

117036, Москва, ул. Дм. Ульянова, д. 11

Yulia S. Absatarova - MD, PhD.

11 Dm. Ulyanova street, 117036 Moscow

korsil2008@yandex.ruГНЦ РФ ФГБУ «Национальный медицинский исследовательский центр эндокринологии им. академика И.И. Дедова» Минздрава РФ; ФГБОУ ВО «Российский университет медицины» Минздрава РФРоссияEndocrinology Research Centre Russia; Russian University of medicineRussian FederationГНЦ РФ ФГБУ «Национальный медицинский исследовательский центр эндокринологии им. академика И.И. Дедова» Минздрава РФРоссияEndocrinology Research Centre RussiaRussian Federation202505112025432027Copyright © Андреева Е.Н., Абсатарова Ю.С., 20252025Андреева Е.Н., Абсатарова Ю.С.Andreeva E.N., Absatarova Y.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vrz-endojournals.ru/jour/article/view/12775

Вазомоторные симптомы в периоде менопаузального перехода встречаются у 80% женщин и могут длиться годами, что серьезно снижает качество жизни. Типичными жалобами пациенток являются приливы жара, повышенная потливость, а также нарушения сна. Лечение и коррекция проблем менопаузального перехода — важные задачи для акушера-гинеколога. На сегодняшний день менопаузальная гормональная терапия является золотым стандартом в купировании приливов и профилактике остеопороза, однако у нее есть противопоказания. Для тех категорий женщин, которые не могут или не хотят из личных предпочтений принимать гормональные препараты, должны быть предложены негормональные альтернативные методы.

В статье представлен обзор возможных вариантов медикаментозного и немедикаментозного воздействия, а также обсуждаются доказательства эффективности и безопасности альтернативных средств, в том числе коррекция диеты с использованием комплекса растительных компонентов и витаминов Эстровэл с целью предотвращения патологического течения климакса и профилактики возраст-ассоциированных состояний. Поиск литературы осуществляли в отечественных (eLibrary, CyberLeninka.ru) и международных (PubMed, Cochrane Library) базах данных. Преимущественным являлся свободный доступ к полному тексту публикаций. Преимущество отдавалось источникам периода 2018–2025 гг., однако в список литературы включены работы, датированные ранее.

Vasomotor symptoms during the menopausal transition occur in 80% of women and can last for years, which seriously reduces the quality of life. Typical complaints of patients include hot flashes, increased sweating, and sleep disorders. Treatment and correction of menopausal transition problems is an important task for an obstetrician-gynecologist. Today, menopausal hormone therapy is the gold standard in stopping hot flashes and preventing osteoporosis, but it has serious limitations and contraindications. For those categories of women who cannot or do not want to take hormonal drugs due to personal preferences, non-hormonal alternative methods should be offered. The article provides an overview of possible options for drug and non-drug interventions, and discusses evidence of the effectiveness and safety of alternative means, including dietary correction using a complex of herbal components and vitamins Estrovel in order to prevent the pathological course of menopause and prevent age-associated conditions. The literature search was carried out in Russian (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases. Free access to the full text of publications was preferred. The selection of sources was prioritized by the period from 2018 to 2025, however, the list of references includes works dated earlier.

менопаузаприливыфитоэстрогеныmenopausehot flashesphytoestrogensReferencesЮренева С.В., Ильина Л.М., Эбзиева З.Х. Менопаузальные вазомоторные симптомы: социальные аспекты, динамика, кардиометаболические риски и возможности гормональной терапии. // Акушерство и гинекология. — 2019. — №1. — С.26-32. doi: https://doi.org/10.18565/aig.2019.L26-32Yureneva SV, Il’ina LM, Ebzieva ZH. Menopauzal’nye vazomotornye simptomy: social’nye aspekty, dinamika, kardiometabolicheskie riski i vozmozhnosti gormonal’noj terapii. Akusherstvo i ginekologiya. 2019;1:26-32 (In Russ.) doi: https://doi.org/10.18565/aig.2019.L26-32Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288(3):321-33. doi: https://doi.org/10.1001/jama.288.3.321Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288(3):321-33. doi: https://doi.org/10.1001/jama.288.3.321Pinkerton JV. Hormone therapy for postmenopausal women. N Engl J Med. 2020;382(5):446–55. doi: https://doi.org/10.1056/NEJMcp1714787Pinkerton JV. Hormone therapy for postmenopausal women. N Engl J Med. 2020;382(5):446–55. doi: https://doi.org/10.1056/NEJMcp1714787Murtaza F, Shirreff L, Huang LN, et al. Quality and readability of online health information on menopausal hormone therapy in Canada: what are our patients reading? Menopause. 2021;29:54-62. doi: https://doi.org/10.1097/GME.0000000000001881Murtaza F, Shirreff L, Huang LN, et al. Quality and readability of online health information on menopausal hormone therapy in Canada: what are our patients reading? Menopause. 2021;29:54-62. doi: https://doi.org/10.1097/GME.0000000000001881“The 2023 Nonhormone Therapy Position Statement of The North American Menopause Society” Advisory Panel. The 2023 nonhormone therapy position statement of The North American Menopause Society. Menopause. 2023;30(6):573-590. doi: https://doi.org/10.1097/GME.0000000000002200“The 2023 Nonhormone Therapy Position Statement of The North American Menopause Society” Advisory Panel. The 2023 nonhormone therapy position statement of The North American Menopause Society. Menopause. 2023;30(6):573-590. doi: https://doi.org/10.1097/GME.0000000000002200Российское общество акушеров-гинекологов. Клинические рекомендации «Менопауза и климактерическое состояние у женщины». 2021 г. https://cr.minzdrav.gov.ru/view-cr/117_2?ysclid=mb7ygm319s416903155Rossijskoe obshhestvo akusherov-ginekologov. Klinicheskie rekomendacii. Menopauza i klimaktericheskoe sostoyanie u zhenshchiny. 2021. (In Russ.) https://cr.minzdrav.gov.ru/view-cr/117_2?ysclid=mb7ygm319s416903155Strelow B, O’Laughlin D, Anderson T, et al. Menopause Decoded: What’s Happening and How to Manage It. J Prim Care Community Health. 2024;15:21501319241307460. doi: https://doi.org/10.1177/21501319241307460Strelow B, O’Laughlin D, Anderson T, et al. Menopause Decoded: What’s Happening and How to Manage It. J Prim Care Community Health. 2024;15:21501319241307460. doi: https://doi.org/10.1177/21501319241307460Lederman S, Ottery FD, Cano A, et al. Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause (SKYLIGHT 1): a phase 3 randomised controlled study. Lancet. 2023;401(10382):1091-1102. doi: https://doi.org/10.1016/S0140-6736(23)00085-5Lederman S, Ottery FD, Cano A, et al. Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause (SKYLIGHT 1): a phase 3 randomised controlled study. Lancet. 2023;401(10382):1091-1102. doi: https://doi.org/10.1016/S0140-6736(23)00085-5Besong C, Philippeaux S, Bham A, et al. Managing Menopause: The Evolving Role of Estrogens, Selective Serotonin Reuptake Inhibitors, and Phytoestrogens in Balancing Hormonal Fluctuations. Cureus. 2024;16(9):e70440. doi: https://doi.org/10.7759/cureus.70440Besong C, Philippeaux S, Bham A, et al. Managing Menopause: The Evolving Role of Estrogens, Selective Serotonin Reuptake Inhibitors, and Phytoestrogens in Balancing Hormonal Fluctuations. Cureus. 2024;16(9):e70440. doi: https://doi.org/10.7759/cureus.70440Chen MN, Lin CC, Liu CF. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric. 2015;18:260–269. doi: https://doi.org/10.3109/13697137.2014.966241Chen MN, Lin CC, Liu CF. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric. 2015;18:260–269. doi: https://doi.org/10.3109/13697137.2014.966241Reed SD, Lampe JW, Qu C, et al. Self-reported menopausal symptoms in a racially diverse population and soy food consumption. Maturitas. 2013;75(2):152–158. doi: https://doi.org/10.1016/j.maturitas.2013.03.003Reed SD, Lampe JW, Qu C, et al. Self-reported menopausal symptoms in a racially diverse population and soy food consumption. Maturitas. 2013;75(2):152–158. doi: https://doi.org/10.1016/j.maturitas.2013.03.003Xiang Z, Ma B, Pei X, et al. Mechanism of action of genistein on breast cancer and differential effects of different age stages. Pharm Biol. 2025;63(1):141-155. doi: https://doi.org/10.1080/13880209.2025.2469607Xiang Z, Ma B, Pei X, et al. Mechanism of action of genistein on breast cancer and differential effects of different age stages. Pharm Biol. 2025;63(1):141-155. doi: https://doi.org/10.1080/13880209.2025.2469607Mukund V, Behera SK, Alam A, et al. Molecular docking analysis of nuclear factor-κB and genistein interaction in the context of breast cancer. Bioinformation. 2019;15(1):11–17. doi: https://doi.org/10.6026/97320630015011Mukund V, Behera SK, Alam A, et al. Molecular docking analysis of nuclear factor-κB and genistein interaction in the context of breast cancer. Bioinformation. 2019;15(1):11–17. doi: https://doi.org/10.6026/97320630015011Chen M, Li S, Srinivasasainagendra V, et al. Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations. Carcinogenesis. 2022;43(3):190–202. doi: https://doi.org/10.1093/carcin/bgac009Chen M, Li S, Srinivasasainagendra V, et al. Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations. Carcinogenesis. 2022;43(3):190–202. doi: https://doi.org/10.1093/carcin/bgac009Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: https://doi.org/10.3322/caac.21660Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: https://doi.org/10.3322/caac.21660Wan MLY, Co VA, El-Nezami H. Endocrine disrupting chemicals and breast cancer: a systematic review of epidemiological studies. Crit Rev Food Sci Nutr. 2022:62(24):6549–6576. doi: https://doi.org/10.1080/10408398.2021.1903382Wan MLY, Co VA, El-Nezami H. Endocrine disrupting chemicals and breast cancer: a systematic review of epidemiological studies. Crit Rev Food Sci Nutr. 2022:62(24):6549–6576. doi: https://doi.org/10.1080/10408398.2021.1903382Shu XO, Zheng Y, Cai H, et al. Soy food intake and breast cancer survival. JAMA. 2009;302(22):2437-2443. doi: https://doi.org/10.1001/jama.2009.1783Shu XO, Zheng Y, Cai H, et al. Soy food intake and breast cancer survival. JAMA. 2009;302(22):2437-2443. doi: https://doi.org/10.1001/jama.2009.1783Chen LR, Ko NY, Chen KH. Isoflavone Supplements for Menopausal Women: A Systematic Review. Nutrients. 2019;11(11):2649. doi: https://doi.org/10.3390/nu11112649Chen LR, Ko NY, Chen KH. Isoflavone Supplements for Menopausal Women: A Systematic Review. Nutrients. 2019;11(11):2649. doi: https://doi.org/10.3390/nu11112649Simon JA, Davis SR, Lindén Hirschberg A, et al. State of the art in menopause: current best practice approaches from the IMS World Congress 2024, Melbourne. Climacteric. 2025;28(2):98-103. doi: https://doi.org/10.1080/13697137.2025.2457993Simon JA, Davis SR, Lindén Hirschberg A, et al. State of the art in menopause: current best practice approaches from the IMS World Congress 2024, Melbourne. Climacteric. 2025;28(2):98-103. doi: https://doi.org/10.1080/13697137.2025.2457993Thurston RC, Aslanidou Vlachos HE, Derby CA, et al. Menopausal Vasomotor Symptoms and Risk of Incident Cardiovascular Disease Events in SWAN. J Am Heart Assoc. 2021;10(3):e017416. doi: https://doi.org/10.1161/JAHA.120.017416Thurston RC, Aslanidou Vlachos HE, Derby CA, et al. Menopausal Vasomotor Symptoms and Risk of Incident Cardiovascular Disease Events in SWAN. J Am Heart Assoc. 2021;10(3):e017416. doi: https://doi.org/10.1161/JAHA.120.017416Blanco Mejia S, Messina M, Li SS, et al. A meta-analysis of 46 studies identified by the FDA demonstrates that soy protein decreases circulating LDL and total cholesterol concentrations in adults. J. Nutr. 2019;149(6):968–981. doi: https://doi.org/10.1093/jn/nxz020Blanco Mejia S, Messina M, Li SS, et al. A meta-analysis of 46 studies identified by the FDA demonstrates that soy protein decreases circulating LDL and total cholesterol concentrations in adults. J. Nutr. 2019;149(6):968–981. doi: https://doi.org/10.1093/jn/nxz020Naghshi S, Tutunchi H, Yousefi M, et al. Soy isoflavone intake and risk of cardiovascular disease in adults: A systematic review and dose-response meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr. 2024;64(18):6087-6101. doi: https://doi.org/10.1080/10408398.2022.2163372Naghshi S, Tutunchi H, Yousefi M, et al. Soy isoflavone intake and risk of cardiovascular disease in adults: A systematic review and dose-response meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr. 2024;64(18):6087-6101. doi: https://doi.org/10.1080/10408398.2022.2163372Viscardi G, Back S, Ahmed A, et al. Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2025;16(1):100327. doi: https://doi.org/10.1016/j.advnut.2024.100327Viscardi G, Back S, Ahmed A, et al. Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2025;16(1):100327. doi: https://doi.org/10.1016/j.advnut.2024.100327Кузнецова И.В., Войченко Н.А., Кириллова М.Ю. Качество жизни и кардиоваскулярный риск у женщин в периодах менопаузального перехода и постменопаузы. // Медицинский алфавит. — 2020. — №4. — С.39-45Kuznecova IV, Vojchenko NA, Kirillova MYu. Kachestvo zhizni i kardiovaskulyarnyj risk u zhenshchin v periodah menopauzal’nogo perekhoda i postmenopauzy. Medicinskij alfavit. 2020;(4):39-45 (In Russ.)Татарова Н.А., Айрапетян М.С., Жигалова Е.В. Стартовая терапия климактерического синдрома переходного менопаузального периода. // РМЖ. Мать и дитя. — 2017. — Т. 25. — №2. — С. 98–103Tatarova NA, Ajrapetyan MS, Zhigalova EV. Startovaya terapiya klimaktericheskogo sindroma perekhodnogo menopauzal’nogo perioda. RMZh. Mat’ i ditya. 2017; 25(2): 98–103 (In Russ.)Shi V, Morgan EF. Estrogen and estrogen receptors mediate the mechanobiology of bone disease and repair. Bone. 2024;188:117220. doi: https://doi.org/10.1016/j.bone.2024.117220Shi V, Morgan EF. Estrogen and estrogen receptors mediate the mechanobiology of bone disease and repair. Bone. 2024;188:117220. doi: https://doi.org/10.1016/j.bone.2024.117220Aaseth JO, Finnes TE, Askim M, et al. The Importance of Vitamin K and the Combination of Vitamins K and D for Calcium Metabolism and Bone Health: A Review. Nutrients. 2024;16(15):2420. doi: https://doi.org/10.3390/nu16152420Aaseth JO, Finnes TE, Askim M, et al. The Importance of Vitamin K and the Combination of Vitamins K and D for Calcium Metabolism and Bone Health: A Review. Nutrients. 2024;16(15):2420. doi: https://doi.org/10.3390/nu16152420Zoch ML, Clemens TL, Riddle RC. New insights into the biology of osteocalcin. Bone. 2016;82:42–49. doi: https://doi.org/10.1016/j.bone.2015.05.046Zoch ML, Clemens TL, Riddle RC. New insights into the biology of osteocalcin. Bone. 2016;82:42–49. doi: https://doi.org/10.1016/j.bone.2015.05.046Feskanich D, Weber P, Willett WC, et al. Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr. 1999;69(1):74-9. doi: https://doi.org/10.1093/ajcn/69.1.74Feskanich D, Weber P, Willett WC, et al. Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr. 1999;69(1):74-9. doi: https://doi.org/10.1093/ajcn/69.1.74Torbergsen AC, Watne LO, Wyller TB, et al. Vitamin K1 and 25 (OH) D are independently and synergistically associated with a risk for hip fracture in an elderly population: A case control study. Clin. Nutr. 2015;34:101–106. doi: https://doi.org/10.1016/j.clnu.2014.01.016Torbergsen AC, Watne LO, Wyller TB, et al. Vitamin K1 and 25 (OH) D are independently and synergistically associated with a risk for hip fracture in an elderly population: A case control study. Clin. Nutr. 2015;34:101–106. doi: https://doi.org/10.1016/j.clnu.2014.01.016Baez-Gonzalez AS, Carrazco-Carrillo JA, Figueroa-Gonzalez G, et al. Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells. Biochem Biophys Rep. 2023;35:101492. doi: https://doi.org/10.1016/j.bbrep.2023.101492Baez-Gonzalez AS, Carrazco-Carrillo JA, Figueroa-Gonzalez G, et al. Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells. Biochem Biophys Rep. 2023;35:101492. doi: https://doi.org/10.1016/j.bbrep.2023.101492Brandi G, Paiardini M, Cervasi B, et al. A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines. Cancer Res. 2003;63:4028–4036Brandi G, Paiardini M, Cervasi B, et al. A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines. Cancer Res. 2003;63:4028–4036Seyoum Tola F. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA. Medicine (Baltimore). 2024;103(19):e38154. doi: https://doi.org/10.1097/MD.0000000000038154Seyoum Tola F. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA. Medicine (Baltimore). 2024;103(19):e38154. doi: https://doi.org/10.1097/MD.0000000000038154Thornburgh S, Gaskins AJ. B vitamins, polycystic ovary syndrome, and fertility. Curr Opin Endocrinol Diabetes Obes. 2022;29(6):554-559. doi: https://doi.org/10.1097/MED.0000000000000773Thornburgh S, Gaskins AJ. B vitamins, polycystic ovary syndrome, and fertility. Curr Opin Endocrinol Diabetes Obes. 2022;29(6):554-559. doi: https://doi.org/10.1097/MED.0000000000000773Ismail S, Eljazzar S, Ganji V. Intended and Unintended Benefits of Folic Acid Fortification-A Narrative Review. Foods. 2023;12(8):1612. doi: https://doi.org/10.3390/foods12081612Ismail S, Eljazzar S, Ganji V. Intended and Unintended Benefits of Folic Acid Fortification-A Narrative Review. Foods. 2023;12(8):1612. doi: https://doi.org/10.3390/foods12081612Kaye AD, Jeha GM, Pham AD, et al. Folic Acid Supplementation in Patients with Elevated Homocysteine Levels. Adv. Ther. 2020;37:4149–4164. doi: https://doi.org/10.1007/s12325-020-01474-zKaye AD, Jeha GM, Pham AD, et al. Folic Acid Supplementation in Patients with Elevated Homocysteine Levels. Adv. Ther. 2020;37:4149–4164. doi: https://doi.org/10.1007/s12325-020-01474-zFu P, Gibson CJ, Mendes WB, et al. Anxiety, depressive symptoms, and cardiac autonomic function in perimenopausal and postmenopausal women with hot flashes: a brief report. Menopause. 2018;25:12:1470-1475. doi: https://doi.org/10.1097/GME.0000000000001153Fu P, Gibson CJ, Mendes WB, et al. Anxiety, depressive symptoms, and cardiac autonomic function in perimenopausal and postmenopausal women with hot flashes: a brief report. Menopause. 2018;25:12:1470-1475. doi: https://doi.org/10.1097/GME.0000000000001153Bromberger JT, Kravitz HM, Chang Y, et al. Does risk for anxiety increase during the menopausal transition? Study of Women’s Health Across the Nation. Menopause. 2013;20:5:488-495. doi: https://doi.org/10.1097/GME.0b013e3182730599Bromberger JT, Kravitz HM, Chang Y, et al. Does risk for anxiety increase during the menopausal transition? Study of Women’s Health Across the Nation. Menopause. 2013;20:5:488-495. doi: https://doi.org/10.1097/GME.0b013e3182730599Khalili P, Asbaghi O, Aghakhani L, et al. The effects of folic acid supplementation on depression in adults: A systematic review and meta-analysis of randomized controlled trials. Nutr. Food Sci. 2023;53:521–534. doi: https://doi.org/10.1108/NFS-02-2022-0043Khalili P, Asbaghi O, Aghakhani L, et al. The effects of folic acid supplementation on depression in adults: A systematic review and meta-analysis of randomized controlled trials. Nutr. Food Sci. 2023;53:521–534. doi: https://doi.org/10.1108/NFS-02-2022-0043Maki PM, Jaff NG. Brain fog in menopause: a healthcare professional’s guide for decision-making and counseling on cognition. Climacteric. 2022;25(6):570–578. doi: https://doi.org/10.1080/13697137.2022.2122792Maki PM, Jaff NG. Brain fog in menopause: a healthcare professional’s guide for decision-making and counseling on cognition. Climacteric. 2022;25(6):570–578. doi: https://doi.org/10.1080/13697137.2022.2122792Islam MT, Al Shamsh Prottay A, Bhuia MS, et al. Memory-Enhancing Effects of Daidzin, Possibly Through Dopaminergic and AChEergic Dependent Pathways. J Nutr. 2025:S0022-3166(25)00269-X. doi: https://doi.org/10.1016/j.tjnut.2025.04.024Islam MT, Al Shamsh Prottay A, Bhuia MS, et al. Memory-Enhancing Effects of Daidzin, Possibly Through Dopaminergic and AChEergic Dependent Pathways. J Nutr. 2025:S0022-3166(25)00269-X. doi: https://doi.org/10.1016/j.tjnut.2025.04.024Uddenberg ER, Safwan N, Saadedine M, et al. Menopause transition and cardiovascular disease risk. Maturitas. 2024;185:107974. doi: https://doi.org/10.1016/j.maturitas.2024.107974Uddenberg ER, Safwan N, Saadedine M, et al. Menopause transition and cardiovascular disease risk. Maturitas. 2024;185:107974. doi: https://doi.org/10.1016/j.maturitas.2024.107974Thurston RC, Chang Y, Kline CE, et al. Trajectories of sleep over midlife and incident cardiovascular disease events in the Study of Women’s Health Across the Nation. Circulation. 2024;149:7: 545-555. doi: https://doi.org/10.1161/CIRCULATIONAHA.123.066491Thurston RC, Chang Y, Kline CE, et al. Trajectories of sleep over midlife and incident cardiovascular disease events in the Study of Women’s Health Across the Nation. Circulation. 2024;149:7: 545-555. doi: https://doi.org/10.1161/CIRCULATIONAHA.123.066491Martins FO, Conde SV. Gender differences in the context of obstructive sleep apnea and metabolic diseases. Front Physiol. 2021;12:792633. doi: https://doi.org/10.3389/fphys.2021.792633Martins FO, Conde SV. Gender differences in the context of obstructive sleep apnea and metabolic diseases. Front Physiol. 2021;12:792633. doi: https://doi.org/10.3389/fphys.2021.792633Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020;22(1):181. doi: https://doi.org/10.3390/ijms22010181Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020;22(1):181. doi: https://doi.org/10.3390/ijms22010181Cerqueira RO, Frey BN, Leclerc E, et al. Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review. Arch Womens Ment Health. 2017;20:713–719. doi: https://doi.org/10.1007/s00737-017-0791-0Cerqueira RO, Frey BN, Leclerc E, et al. Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review. Arch Womens Ment Health. 2017;20:713–719. doi: https://doi.org/10.1007/s00737-017-0791-0Höller M, Steindl H, Abramov-Sommariva D, et al. Use of Vitex agnus-castus in patients with menstrual cycle disorders: a single-center retrospective longitudinal cohort study. Arch Gynecol Obstet. 2024 May;309(5):2089-2098. doi: https://doi.org/10.1007/s00404-023-07363-4Höller M, Steindl H, Abramov-Sommariva D, et al. Use of Vitex agnus-castus in patients with menstrual cycle disorders: a single-center retrospective longitudinal cohort study. Arch Gynecol Obstet. 2024 May;309(5):2089-2098. doi: https://doi.org/10.1007/s00404-023-07363-4Soleimany Z, Siadat F, Farhadi M, et al. Improvement of ovarian function in a premature ovarian failure mouse model using Vitex agnus-castus extract. JBRA Assist Reprod. 2025;29(1):117-126. doi: https://doi.org/10.5935/1518-0557.20240101Soleimany Z, Siadat F, Farhadi M, et al. Improvement of ovarian function in a premature ovarian failure mouse model using Vitex agnus-castus extract. JBRA Assist Reprod. 2025;29(1):117-126. doi: https://doi.org/10.5935/1518-0557.20240101Kumari R, Thakur A, Thakur P, et al. An Update on the Nutritional and Therapeutic Potential of Dioscorea oppositifolia. Food Sci Nutr. 2025;13(5):e70179. doi: https://doi.org/10.1002/fsn3.70179Kumari R, Thakur A, Thakur P, et al. An Update on the Nutritional and Therapeutic Potential of Dioscorea oppositifolia. Food Sci Nutr. 2025;13(5):e70179. doi: https://doi.org/10.1002/fsn3.70179Lu J, Wong RN, Zhang L, et al. Comparative Analysis of Proteins with Stimulating Activity on Ovarian Estradiol Biosynthesis from Four Different Dioscorea Species in vitro Using Both Phenotypic and Target-based Approaches: Implication for Treating Menopause. Appl Biochem Biotechnol. 2016;180(1):79-93. doi: https://doi.org/10.1007/s12010-016-2084-xLu J, Wong RN, Zhang L, et al. Comparative Analysis of Proteins with Stimulating Activity on Ovarian Estradiol Biosynthesis from Four Different Dioscorea Species in vitro Using Both Phenotypic and Target-based Approaches: Implication for Treating Menopause. Appl Biochem Biotechnol. 2016;180(1):79-93. doi: https://doi.org/10.1007/s12010-016-2084-x

The authors declare that there are no conflicts of interest present.