verezdoВестник репродуктивного здоровьяBulletin of Reproductive Health2075-65692310-421XEndocrinology Research Centre (Moscow)10.14341/brh12780verezdo-12796Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИCASE REPORTSГестационный сахарный диабет у матери и врожденный гиперинсулинизм у пробанда, обусловленные мутацией в гене ABCC8Gestational diabetes mellitus in the mother and congenital hyperinsulinism in the proband, caused by an ABCC8 gene mutationhttps://orcid.org/0000-0002-5322-1021ПлехановаМ. А.PlehanovaM. A.

Плеханова Маргарита Александровна - к.м.н., врач-эндокринолог.

Московская область

Margarita A. Plechanova - MD.

Moscow Regional

margarita_kr@list.ruhttps://orcid.org/0000-0001-9943-0964БурумкуловаФ. Ф.BurumkulovaF. F.

Бурумкулова Фатима Фархадовна - д.м.н., в.н.с.

Московская область

Fatima F. Burumkulova - MD, PhD, leading research associate.

Moscow Regional

fatima-burumkulova@yandex.ruМосковский областной НИИ акушерства и гинекологии им. академика В.И. КраснопольскогоРоссияMoscow Regional Research Institute of Obstetrics and GynecologyRussian Federation202626042026011417Copyright © Плеханова М.А., Бурумкулова Ф.Ф., 20262026Плеханова М.А., Бурумкулова Ф.Ф.Plehanova M.A., Burumkulova F.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vrz-endojournals.ru/jour/article/view/12796

Наиболее частой причиной гипогликемии у новорожденных является фетальная гиперинсулинемия в ответ на гипергликемию у материи, а пусковым механизмом ее развития является отделение плаценты в родах и прекращение поступлении глюкозы на фоне гиперсекреции инсулина. Такая гипогликемия длится обычно до трех суток. Более длительная и тяжелая гипогликемия ставит вопрос о генетической природе данного состояния и описана при мутации в генах HNF4A, HNF1A, GCK и ABCC8.

The most common cause of hypoglycemia in newborns is fetal hyperinsulinemia in response to maternal hyperglycemia, and the triggering mechanism for its development is placental separation during delivery, which abruptly stops glucose supply while insulin secretion remains elevated. Such hypoglycemia typically lasts up to three days. Persistent and severe hypoglycemia beyond this period raises suspicion of a genetic etiology and has been described in cases of mutations in the HNF4A, HNF1A, GCK, and ABCC8 genes.

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The authors declare that there are no conflicts of interest present.