verezdoВестник репродуктивного здоровьяBulletin of Reproductive Health2075-65692310-421XEndocrinology Research Centre (Moscow)10.14341/brh20083-425-28verezdo-8536Research ArticleСтатьиArticlesВлияние эстрогенов на ЦНСVliyanie estrogenov na TsNSИловайскаяИ АIlovayskayaI A-МихайловаД СMikhaylovaD S-ММА им. И.М. Сеченова20081512200803-4№3-4 (2008)2528Copyright © Иловайская И.А., Михайлова Д.С., 20082008Иловайская И.А., Михайлова Д.С.Ilovayskaya I.A., Mikhaylova D.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vrz-endojournals.ru/jour/article/view/8536

Эстрогены в организме женщины контролируют развитие половых органов, участвуют в становлении функциональной активности гипоталамо-гипофизарно-гонадной системы и обеспечивают репродуктивную функцию. Кроме того, они выполняют такие«нерепродуктивные» функции, как обеспечение развития и дифференцировки клеток мозга на различных этапах онтогенеза, влияние на нейроэндокринную регуляцию обменных процессов и регенераторных и пластических процессов в центральной нервной системе (ЦНС), обеспечение формирования поведенческих, психологических и половых реакций. Эстрогены оказывают важное защитное действие на ЦНС: замедляют процессы апоптоза клеток ЦНС и повышают их выживаемость в условиях гипоксии, гипогликемии и интоксикации. Половые стероиды участвуют в формировании когнитивных функций, уменьшают клинические проявления депрессии и других психических расстройств. Понимание влияния эстрогенов на развитие и функционирование ЦНС в различные периоды жизни женщин чрезвычайно важно для выбора тактики лечения различных дисгормональных нарушений у женщин и определения показаний и противопоказаний к применению гормональных или антигормональных препаратов.

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The authors declare that there are no conflicts of interest present.