verezdoВестник репродуктивного здоровьяBulletin of Reproductive Health2075-65692310-421XEndocrinology Research Centre (Moscow)10.14341/brh200912-5verezdo-8543Research ArticleСтатьиArticlesРиск развития сердечно-сосудистых заболеваний у женщин с ожирением в менопаузеRisk razvitiya serdechno-sosudistykh zabolevaniy u zhenshchin s ozhireniem v menopauzeМазуринаН ВMazurinaN V-ФГУ Эндокринологический научный центр20091503200901№1 (2009)25Copyright © Мазурина Н.В., 20092009Мазурина Н.В.Mazurina N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vrz-endojournals.ru/jour/article/view/8543

Сердечно-сосудистые заболевания (ССЗ) и переломы, связанные с остеопорозом, являются важнейшими причинами, определяющими смертность в старших возрастных группах [1, 2]. В настоящее время хорошо известно, что риск развития как ССЗ, так и остеопороза у женщин существенно возрастает с момента наступления менопаузы [1, 3]. Ожирение и избыточная масса тела, распространенность которых в экономически развитых странах достигает 30%, также во многом определяют структуру заболеваемости и смертности. Так, по данным исследования NHANES III, имеется четкая зависимость между индексом массы тела (ИМТ) и частотой развития сахарного диабета (СД) 2 типа, ишемической болезни сердца (ИБС), артериальной гипертензии (АГ), остеоартроза (см. таблицу). В целом, у женщин с ожирением риск смерти от ССЗ возрастает в 5 раз [4]. Женщины в постменопаузе составляют80% всех лиц, страдающих остеопорозом [1]. Постменопаузальный остеопороз развивается у 25–40% женщин, причем имеется положительная корреляция между ИМТ и минеральной плотностью костной ткани (МПКТ), т.е. частота развития остеопороза уменьшается у лиц с более высоким ИМТ. В то же время частота развития дегенеративных заболеваний опорно-двигательного аппарата, таких как остеоартроз, остеохондроз, спондилез, увеличивается по мере увеличения массы тела [4].

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The authors declare that there are no conflicts of interest present.