This issue of reproductive medicine news presents the most relevant meta-analysis data, as well as innovative methods in the treatment of diseases of the reproductive system, presented in leading international periodicals in 2024. The main conclusions of the clinical recommendations of the European Society for Human Reproduction on the management of married couples with recurrent implantation failures are also briefly formulated.

Menopausal symptoms can disrupt the life course of women at the peak of their career and family life. Currently, the most effective treatment for these manifestations is menopausal hormone therapy (MHT). The presence of cardiovascular and metabolic diseases in itself does not exclude the possibility of prescribing MHT to relieve menopausal symptoms and improve quality of life. However, often an obstacle to the use of this type of hormonal therapy is the fear of doctors who are afraid of doing more harm to patients than good. Caution is especially important when it comes to women with underlying health conditions. Moreover, it should be recognized that there is a lack of high-quality research regarding the safety of MHT for major chronic non-infectious diseases and common comorbid conditions. The presented consensus document analyzed all currently available data obtained from clinical trials of various designs and created a set of criteria for the acceptability of prescribing MHT to women with concomitant cardiovascular and metabolic diseases. Based on the presented document, doctors of various specialties who advise women in menopause will receive an accessible algorithm that will allow them to avoid potentially dangerous situations and reasonably prescribe MHT in real practice.

Male hypogonadism and type 2 diabetes mellitus (T2DM) are often combined and aggravate each other. Considering the pathogenetic relationship with the components of the metabolic syndrome (hyperglycemia, insulin resistance, obesity) and the potential reversibility of testosterone deficiency, as well as the wariness of doctors and patients regarding testosterone replacement therapy, it is interesting to study the effect of various methods for correcting carbohydrate metabolism and obesity on endogenous testosterone production. When analyzing the effect of lifestyle correction, drug therapy for T2DM and obesity, as well as metabolic surgery on testosterone production, encouraging results were obtained with regard to methods that provide, first of all, significant reduction in body weight (medications from the group of glucagon-like peptide-1 receptor agonists and bariatric surgery). As for other classes of new antidiabetic drugs, it is likely that all of them may have direct or indirect beneficial effects on male sexual function, mainly by reducing glucotoxicity and inflammation. However, this hypothesis requires studies on large samples of patients. In addition, there is still no convincing data on the significance of correction of carbohydrate metabolism, regardless of weight loss, in relation to endogenous testosterone production, and there is also no data on the degree of improvement in glycemic control required for a clinically significant increase in serum testosterone levels.

This article presents main historical moments of formation and evolution of Andrology & Urology Department of the Endocrinology Research Centre, since its establishment in 2016. The mission of the present scientifical and clinical subdivision is organization of medical aid for males with sexual and reproductive disorders caused by endocrinopathies. The crew of the Andrology & Urology Department provides scientific researches of hormonal and reproductive impairment among ageing males, testosterone replacement. This historical and analytic review presents you biographical datas and graphic materials about leaders of the Departments in the period from the 1960 until 2024. The authors dedicate the present article to teachers and scientific supervisors.

Constant improvement of professional skills and competence are essential components of modern post diploma medical education in the 21st century. Despite of world-wide spread of evidence-based medicine many physicians from such areas as obstetrics, gynecology, andrology, endocrinology, cardiology. gerontology etc. still use outdated and incorrect terminology from reproductive medicine. The such unfavourable trend leads to serious increasement of insufficient/overdiagnosis, treatment mistakes and poor outcomes such as sexual dysfunction, infertility and comorbidity. The present article presents actual interpretations and characterization of gynecological and andrological terms such us menopausal hormonal therapy (MHT) and hormone replacement therapy (HRT) among females and male hypogonadism.

This short message presents main information about Centre for Treatment of Pregnant Females with endocrinopathies. The aim of the present Centre is organization planning and dynamic control of pregnancy for females with endocrinopathies.