On February 12, 2021, Ivan I. Dedov, Academician of the Russian Academy of Sciences, chief endocrinologist of the Russian ministry of health, full cavalier of the Order «For Merit to the Fatherland», Hero of Labour of the Russian Federation, an outstanding scientist and experienced healthcare organizer, celebrates his anniversary. Ivan I. Dedov became chief endocrinologist in very difficult period of Russian history and finally, his name has been given to the name of Endocrinology Research Centre. The list of Ivan I. Dedov’s achievements is extremely huge, that’s why there is not enough place to publish it even in a few issues of journal issues.

The editorial board of the journal "Bulletin of Reproductive Health" cordially congratulates Mr. Ivan I. Dedov, wishes him good health, power for new scientifical achievements and always stay the guiding star for Russian and global endocrinological community!

This issue of reproductive medicine news presents current research and data from reviews and meta-analyses on the study and innovative methods of treating diseases of the reproductive system, presented in leading international periodicals.

The most common cause of hypoglycemia in newborns is fetal hyperinsulinemia in response to maternal hyperglycemia, and the triggering mechanism for its development is placental separation during delivery, which abruptly stops glucose supply while insulin secretion remains elevated. Such hypoglycemia typically lasts up to three days. Persistent and severe hypoglycemia beyond this period raises suspicion of a genetic etiology and has been described in cases of mutations in the HNF4A, HNF1A, GCK, and ABCC8 genes.

The widespread use of anabolic steroids (AS) in sports and recreational fitness has led to an increase in the frequency of iatrogenic hypogonadotropic hypogonadism among men. This condition, characterized by the suppression of the hypothalamic-pituitary-gonadal (HPG) axis via negative feedback, manifests as severe testosterone deficiency, impaired spermatogenesis, and a wide range of negative clinical symptoms. This review systematizes current data on the methods for correcting AAS induced hypogonadism. Unlike similar works, the emphasis is placed on the pathogenetic rationale for choosing a therapeutic strategy based on clearly defined clinical goals: rapid relief of symptoms versus restoration of fertility. It provides a detailed analysis not only of classical testosterone replacement therapy but also of methods aimed at restoring endogenous steroidogenesis and spermatogenesis: therapy with gonadotropins and selective estrogen receptor modulators. Particular attention is paid to prognostic factors for treatment success, including the duration and nature of prior AAS use. Based on the analyzed data, a systematic approach to patient management is proposed, emphasizing the need for treatment individualization. The review also contains a assessment of the potential role of selective androgen receptor modulators (SARM) and an analysis of the likelihood of spontaneous recovery of HPG axis function.

Polycystic ovary syndrome (PCOS) is a polygenic endocrine disorder caused by genetic, hormonal, and epigenetic factors. Its worldwide relevance stems from its prevalence, which ranges from 10% to 13%, as well as the development of associated conditions that negatively impact a woman’s health and well-being: infertility, dermatological manifestations of hyperandrogenism (hirsutism, acne), cardiovascular pathologies, and metabolic and psychoemotional disorders. Compensatory hyperinsulinemia due to insulin resistance is observed in approximately 80% of women with PCOS and obesity, and in 30–40% of normosthenic women diagnosed with PCOS. Therefore, insulin sensitizers are widely used to correct carbohydrate metabolism disorders in women with PCOS. In addition to metformin, the use of inositol for the prevention of metabolic disorders in women with PCOS is actively discussed in the literature and clinical guidelines (both international and Russian). In the last decade, various studies have shown that insulin resistance can be caused by a defect in the second messenger inositol phosphoglycan (IPG), with altered metabolism of inositol or IPG mediators potentiating insulin resistance. Inositol is a vitamin B complex and is epimerized in the body into nine stereoisomers, of which myo-inositol and D-chiro-inositol are the most biologically significant and studied. Myo- and dechiro-inositols can influence intracellular metabolic processes by activating key enzymes involved in oxidative and non-oxidative glucose metabolism. In recent decades, the role of inositols in the regulation of menstrual and ovulatory function has been actively discussed, including in patients with PCOS. The article presents a review of modern Russian and international publications regarding the positive effects of inositol stereoisomers in patients with PCOS in reproductive age.

The present review contains information about features and effects of oral contraceptives containing 75 mcg of desogestrel. Oral contraceptive pills containing 75 mcg of desogestrel are safe for mothers and babies on breastfeeding. Oral contraceptive pills containing 75 mcg of desogestrel. Progestogen-only pills containing 75 mcg of desogestrel ("mini pills") are reliable and safe for contraception among patients with high risk of venous and arterial thrombosis, contraindications for estrogenes, smoking addiction, high metabolic risks (obesity, diabetes mellitus type 2) including females 45 years old and older.

Menopausal symptoms can disrupt the lives of women at the peak of their careers and family life. Currently, the most effective treatment for these symptoms is menopausal hormone therapy (MHT). The presence of cardiovascular and metabolic diseases does not preclude the use of MHT to relieve menopausal symptoms and improve quality of life. However, physicians’ concerns about causing more harm than good often hinder the use of this type of hormone therapy. Caution is especially important when it comes to women with comorbidities. Moreover, it should be acknowledged that high-quality studies on the safety of MHT for major chronic noncommunicable diseases and common comorbid conditions are insufficient. This consensus document analyzes all currently available data from clinical trials of various designs and develops a set of eligibility criteria for prescribing MHT to women with comorbid cardiovascular and metabolic diseases. Based on this document, physicians of various specialties who consult with women in menopause will receive an accessible algorithm that will allow them to avoid potentially dangerous situations and appropriately prescribe HRT in clinical practice