Особенности синдрома гипогонадизма у мужчин с ожирением

Во многих эпидемиологических исследованиях обнаружена взаимосвязь между выработкой тестостерона и ожирением. Особенностью ожирения у мужчин является отложение жировой ткани преимущественно в области живота, то есть абдоминальный характер, что приводит к изменению метаболизма половых гормонов. В основе этого лежит двунаправленная взаимосвязь между ожирением и низким уровнем тестостерона через ароматизацию андрогенов, лептинорезистентность, депонирование тестостерона, а также воздействие других коморбидных факторов. В последние годы отмечается повышенный интерес к этой проблеме, и уже накоплены данные, подтверждающие связь между ожирением и снижением уровня тестостерона у мужчин, которые представлены в публикуемом обзоре. При этом снижение жировой массы тела можно рассматривать как подход к коррекции гипогонадизма, ассоциированного с метаболическими нарушениями, так как гипогонадизм, который развивается на фоне метаболических нарушений, является потенциально обратимым.

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