Gestational diabetes mellitus in the mother and congenital hyperinsulinism in the proband, caused by an ABCC8 gene mutation
https://doi.org/10.14341/brh12780
Abstract
The most common cause of hypoglycemia in newborns is fetal hyperinsulinemia in response to maternal hyperglycemia, and the triggering mechanism for its development is placental separation during delivery, which abruptly stops glucose supply while insulin secretion remains elevated. Such hypoglycemia typically lasts up to three days. Persistent and severe hypoglycemia beyond this period raises suspicion of a genetic etiology and has been described in cases of mutations in the HNF4A, HNF1A, GCK, and ABCC8 genes.
About the Authors
M. A. Plehanova
Moscow Regional Research Institute of Obstetrics and Gynecology
Russian Federation
Competing Interests:
Russian Federation
Margarita A. Plechanova - MD.
Moscow Regional
Competing Interests:
none
F. F. Burumkulova
Moscow Regional Research Institute of Obstetrics and Gynecology
Russian Federation
Competing Interests:
Russian Federation
Fatima F. Burumkulova - MD, PhD, leading research associate.
Moscow Regional
Competing Interests:
none
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Review
For citations:
Plehanova M.A., Burumkulova F.F. Gestational diabetes mellitus in the mother and congenital hyperinsulinism in the proband, caused by an ABCC8 gene mutation. Bulletin of Reproductive Health. 2026;(1):14-17. (In Russ.) https://doi.org/10.14341/brh12780
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