Kriptorkhizm proyavlenie sindroma testikulyarnoy disgenezii
https://doi.org/10.14341/brh20083-42-7
Abstract
В последние годы отмечается рост интереса к крипторхизму и другим заболеваниям репродуктивной системы, манифестирующим в детском возрасте (гипоспадия, варикоцеле, пахово-мошоночная грыжа, сперматоцеле, гидроцеле). Это связано с высоким риском развития у данных пациентов во взрослом возрасте специфических осложнений: бесплодия, гипогонадизма, рака яичка (Ря) и эректильной дисфункции. Так, данные E. Nieschlag и H.M. Behre, полученные при обследовании 5061 пациента с нарушением репродуктивной функции, свидетельствуют, что ведущими причинами мужского бесплодия являются заболевания, развивающиеся в детском возрасте: варикоцеле (15%), гипогонадизм (10%), крипторхизм (8%) [1].
References
1. Nieschlag E., Behre H.M. Male infertility due to testicular dysfunction. In Templeton A.A., Drife J.O. (eds): Infertility. London: Springer-Verlag 1992.
2. Berkowitz G.S., Lapinski R.H., Dolgin S.E. et al. Prevalence and natural history of cryptorchidism. Pediatrics 1993; 92: 44–49.
3. Lee P.A., Coughlin M.T. Fertility after bilateral cryptorchidism: Evaluation by paternity, hormone and semen data. Hormone Res 2001; 55: 28–32.
4. Cortes D., Thorup J.M., Visfeldt J. Cryptorchidism: aspects of fertility and neoplasms. Horm Res 2001; 55: 21–27.
5. Hutson J.M., Hasthorpe S. Testicular descent and cryptorchidism: the state of the art in 2004. Eur J Pediatr Surg 2005; 40: 297–302.
6. Elert A., Jahn K., Yeidenreich A., Hofmann R. The familial undescended testis. Klin Pediatr 2003; 215: 40–45.
7. Hutson J.M., Hasthorpe S., Heyns C.F. Anatomical and functional aspects of testicular descent and cryptorchidism. Endocrine Rev 1997; 18: 259–280.
8. Smith J.F., Wayment R.O., Cartwright P.C. et al. Genitourinary anomalies of pediatric FG syndrome. J Urol 2007; 178: 656–659.
9. Ferlin A., Simonato M., Bartoloni L. et al. The INSL3-LGR8/ GREAT ligand-receptor pair in human cryptorchidism. Eur J Pediatr Surg 2003; 88: 4273–4279.
10. Ong C., Hasthorpe S., Hutson J.M. Germ cell development in the descended and cryptorchid testis and the effects of hormonal manipulation. Eur J Pediatr Surg 2005; 21: 240–254.
11. Crew F.A.E. A suggestion as to the cause of the aspermatic condition of the imperfectly descended testis. J Anatomy 1921; 56:98.
12. Moore C.R., Oslund J.K. Experimental studies on sheep testes. Amer Soc Zool Anat Rec 1923; 26: 343.
13. Zini A., Abitbol J., Schulsinger D. et al. Restoration of spermatogenesis after scrotal replacement of experimentally cryptorchid rat testis: assessment of germ cell apoptosis and eNOS expression. Urology 1999; 53 (1): 223–227.
14. Huff D.S., Hadziselimovic F., Snyder H.M. III et al. Early postnatal testicular maldevelopment in cryptorchidism. J Urol 1991; 146: 624–626.
15. Hadziselimovic F., Herzog B. The development and descent of the epididymis. Eur J Pediatr Surg 1993; 152: 6–9.
16. Shakkebaek N.E., Rajpert-De Meyts E., Main K.M. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 2001; 16: 972– 978.
17. Olesen I.A., Sonne S.B., Hoei-Hansen C.E. et al. Environment testicular dysgenesis and carcinoma in situ testis. Best Pract Res Clin Endocrinol Metab 2007; 21: 462–468.
18. Stillman R.J. In utero exposure to diethylstilbestrol: adverse effects on reproductive tract and reproductive performance and male and female offspring. Am J Obset Gynecol 1982; 142: 905– 921.
19. Norie Kurahashi, Setsuco Kasai, Takashi Shibata et al. Parental and neonatal risk factors for cryptorchidism. Med Sci Monit 2005;11 (6): CR274–283.
20. Biggs M.L., Bear A., Critchlow C.W. Maternal, delivery, and perinatal characteristics associated with cryptorchidism: a population-based case-control study among birth in Washington State. Epidimiology 2002; 13: 197–204.
21. Kizu R., Okamura K., Toriba A. et al. Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cells. Toxicol Sci 2003; 76: 835–842.
22. Yoshida S., Sagai M., Oshio S. et al. Exposure to diesel exhaust effects the male reproductive system of mice. Int J Androl 1999; 22: 305–317.
23. North K. A maternal vegetarian diet in pregnancy in associated with hypospadias. BJU Int. 2000; 85: 107–113.
24. Савченков А.Л., Тарасов А.А., Подгорный А.Н. и др. Врожденный крипторхизм в структуре оперативных вмешательств у детей. Материалы 5-го Российского научного Форума «Мужское здоровье и долголетие». М 20–22 февраля 2007; 83.
25. Sharpe R.M. The «oestrogen hypotesis» — where do we stand now? Int J Androl 2003; 26: 2–15.
26. Kester M.N., Bulduk S., van Toor H. et al. Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals altemative mechanism for estrogenic activity of endocrine disrupters. J Clin Endocrinol Metab 2002; 87: 1142–1150.
27. Yoshida R., Fukami M., Sasagava I. et al. Association of cryptorchidism with a specific haplotype of the estrogen receptor alpha gene: implication for the susceptibility to estrogenic environmental endocrine disruptors. J Clin Endocrinol Metab 2005; 90: 4716–4721.
28. Galah J.J., Guarducci E., Nuti F. et al. Molecular analysis of estrogen receptor alpha gene AGATA haplotype and S NP12 in European population: potential protective effect for cryptorchidism and lack of association with male infertility. Hum Reprod 2007; 22: 444–449.
29. Silva-Ramos M., Oliveira J.M., Cabeda J.M. et al. The CAG repeat within the androgen receptor gene and its relationship to cryptorchidism. Int Braz J Urol 2006; 32: 330–334.
30. Лаврова Т.Р., Пыков М.И, Смирнов В.Ф. и др. Тестикулярный микролитиаз у детей: распространенность при заболеваниях репродуктивной системы, ультразвуковая оценка. Ультразвуковая и функциональная диагностика 2007; 3: 62–74.
Review
For citations:
Latyshev O.Yu., Lavrova T.R., Mirakov K.K., Samsonova L.N., Okulov A.B., Kasatkina E.P. Kriptorkhizm proyavlenie sindroma testikulyarnoy disgenezii. Bulletin of Reproductive Health. 2008;(3-4):2-7. (In Russ.) https://doi.org/10.14341/brh20083-42-7
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