This preambular is dedicated to the revival of the medical journal «Bulletin of Reproductive Health» after long pausal period which lasted 12 years, from 2011 until 2023. This period was remarkable due to serious progressive changes in understanding of etiology, pathogenesis, diagnostics and treatment of reproductive pathologies among males and females. Historical transit from clinical medicine to personalized medicine has been continuing due to development of evidence-based medicine. The staff of “Bulletin of reproductive health” sets a goal to continue providing access to clinical, experimental, fundamental researches, reviews, lectures, clinical cases, discussions, world digests for actual problems of reproductive medicine.

This article presents the historical review of establishment and formation of reproductive medicine department included since 2016 into the Institute for Reproductive Medicine (Endocrinology Research Centre, Moscow, Russian Federation). The basic aim of establishment of the Institute for Reproductive Medicine are coordination between its subdivisions effective treatment and scientific researches among patients with reproductive pathologies and endocrinopathies. The review is supplied with biographical and graphic datas about all leaders of reproductive medical departments from the 1960s until 2020s such as endocrinological gynecology, assisted reproductive technologies, andrology & urology. Authors; group dedicates the present article to scientific supervisors and mentors.

This issue of reproductive medicine news presents the most relevant meta-analysis data, as well as innovative methods in the treatment of diseases of the reproductive system, presented in leading international periodicals in 2023. The present issue includes 5 most actual headings chosen according to editing stuff’s professional opinion. The present digest includes conclusions of the clinical recommendations of the European Society for Human Reproduction (ESHRE) on the management of married couples with recurrent implantation failures, features of SARS-CoV-2 influence on reproductive system and HRT success rate, features of social stress on fetal survival, postnatal outcomes after using of HRT are also briefly formulated.

Amenorrhea is the absence or abnormal cessation of the menstrual cycle. Functional hypothalamic amenorrhea (FHA) is one of the most common and least studied forms of secondary (hypothalamic) amenorrhea that occurs after adaptation failure in response to mental, social and metabolic irritants. At there are no common threshold values of potential irritants and markers of efficacy for female patioents with FHA. Methods of diagnostics, treatment and prevention of FHA stay still not personalized, but empirical. The most promising solution of present problem is combination of nutritive and mental correction among females with FHA. Also, the most promising step is searching and studying of omics (genomic, epigenomic, transcriptomic, proteomic and metabolomic) markers of hypothalamic–hypophysial-gonadal axis disruption. This review shows the association between amenorrhea and stress, changes in nutrition or weight, excessive physical activity, and the COVID-19 pandemic. The literature was searched in Russian and English languages in eLibrary, MEDLINE, and Scopus databases mainly for the last decade. Due to the insufficient study of the chosen topic, sources dating back to the 1990s were also selected.