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Iron deficiency states in metabolically burdened women in the pregravid period

https://doi.org/10.14341/brh12761

Abstract

Anemia is the most common health problem, especially among women. Iron deficiency affects approximately 4 billion people on the planet (more than 60% of the world’s population), and iron-deficiency anemia is diagnosed in almost 2 billion people. Regardless of age, the most common causes of decreased hemoglobin are iron and folate deficiency. The systemic effects of anemia of any etiology can lead to a significant deterioration in the quality of life of patients. The etiology of each deficiency condition may differ at different periods of a woman’s life, but for women of reproductive age, the significance of the clinical consequences of anemia is greatest, since the adverse effects of deficiency not only affect their body, but can also affect pregnancy outcomes and the health of newborns. Iron deficiency is one of the comorbidities in obese patients, which allows us to distinguish a special phenotype («iron deficiency») of obesity. There is convincing evidence of a pathogenetic link between iron deficiency and the presence of systemic inflammation associated with obesity. In order to prevent and correct deficiency conditions in women of reproductive age, treatment regimens using iron, folic acid, B12 or their combinations have been developed and introduced into practice.

About the Authors

E. N. Andreeva
Endocrinology Research Centre; Russian University of Medicine
Russian Federation

Elena N. Andreeva, MD, PhD, professor


Competing Interests:

Авторы декларируют отсутствие явных и  потенциальных конфликтов интересов, связанных с содержанием настоящей статьи



E. V. Sheremetyeva
Endocrinology Research Centre
Russian Federation

Ekaterina V. Sheremetyeva, MD, PhD

11 Dm. Ulyanova street, 117036 Moscow


Competing Interests:

Авторы декларируют отсутствие явных и  потенциальных конфликтов интересов, связанных с содержанием настоящей статьи



References

1. Federal State Statistics Service, https://rosstat.gov.ru/free_doc/new_site/food23/index.html

2. Healthcare in Russia. 2023: Statistical Collection/ Rosstat. — M., Z-46 2023. — 179 p.

3. Bondarenko A.S. Role status and relationships between doctor and patient in the prevention of gynecological diseases: Abstract of a dissertation for the degree of candidate of medical sciences. — Volgograd, 2015

4. Analytical center NAFI, Moscow, 2023, https://nafi.ru/

5. World Health Organization, 2023, https://www.who.int/ru/news-room/fact-sheets/ detail/anaemia

6. Global Health Metrics. Anaemia–Level 1 impairment. Lancet. 2019;393

7. Vinogradova M.A., Fedorova T.A., Strelnikova E.V., Bakuridze E.M., Rogachevsky O.V. Anemia in women of reproductive age // Obstetrics and Gynecology. — 2014. — No. 11. — P. 107-112.

8. Arutyunyan A.A., Serdyukov A.G. Study of the medical and social status of rural women with menstrual cycle disorders // Modern Problems of Science and Education. — 2015. — No. 5.

9. Polyakova O.A., Klepikova M.V., Litvinova S.N., Isaakyan Yu.A., Ostroumova O.D. The problem of iron deficiency and iron deficiency anemia in general medical practice. // Preventive medicine. — 2022. — V.25. — No. 12. — P. 127-134. doi: https://doi.org/10.17116/profmed202225121127

10. Bolotova E.V., Dudnikova A.V., Krutova V.A. Frequency and characteristics of iron deficiency conditions in women of reproductive age. // Clinical Medicine. — 2020. — Vol. 98. — No. 4. — P. 287-293. doi: http://dx.doi.org/10.34651/0023-2149-2020-98-4-287-293

11. Pregravid preparation. Clinical protocol of the Interdisciplinary Association of Reproductive Medicine Specialists (MARS). Version 2.0 / [Collective authors]. — M .: Editorial office of the StatusPraesens journal, 2020. — 128 p.

12. https://www.gazeta.ru/social/news/2023/10/13/21492283.shtml

13. Clinical guidelines «Normal pregnancy», Moscow, 2023

14. Dedov I.I., Shestakova M.V., Melnichenko G.A., Mazurina N.V., Andreeva E.N., et al. Interdisciplinary clinical guidelines «Treatment of obesity and comorbid diseases». // Obesity and Metabolism. — 2021. — Vol. 18. — No. 1. — P. 5-99. doi: https://doi.org/10.14341/omet12714

15. Clinical guidelines “Abnormal uterine bleeding”, Moscow, 2024, draft

16. https://www.rosmedlib.ru/

17. Global alcohol action plan 2022-2030 to strengthen implementation of the Global Strategy to Reduce the Harmful Use of Alcohol, First draft, June 2021

18. Seltzer CC, Mayer J. Serum Iron and Iron-Binding Capacity in Adolescents. II. Comparison of Obese and Nonobese Subjects. Am J Clin Nutr. 1963;13 (6):354-361 doi: https://doi.org/10.1093/ajcn/13.6.354

19. Bertinato J, Aroche C, Plouffe LJ, et al. Diet-induced obese rats have higher iron requirements and are more vulnerable to iron deficiency. Eur J Nutr. 2014;53(3):885-895. doi: https://doi.org/10.1007/s00394-013-0592-9

20. Ruivard M, Lainé F, Ganz T, et al. Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. J Hepatol. 2009;50(6):1219-1225. doi: https://doi.org/10.1016/j.jhep.2009.01.029

21. Aigner E, Feldman A, Datz C. Obesity as an Emerging Risk Factor for Iron Deficiency. Nutrients. 2014;6(9):3587-3600. doi: https://doi.org/10.3390/nu6093587

22. Clinical guidelines «Iron deficiency anemia», Moscow, 2024

23. Clinical guidelines «Vitamin D deficiency in adults», Moscow, 2022

24. Algorithms of specialized medical care for patients with diabetes mellitus / Edited by I.I. Dedov, M.V. Shestakova, A.Yu. Mayorov. 11th issue, 2024

25. Resolution of the expert council on iron deficiency anemia in women // Obstetrics and Gynecology: news, opinions, training. 2020. Vol. 8. — No. 4. — P. 28-36. doi: https://doi.org/10.24411/2303-9698-2020-14004

26. Nikzad Z, Iravani M, Abedi P, Shahbazian N, Saki A. The relationship between iron deficiency anemia and sexual function and satisfaction among reproductive-aged Iranian women. PLoS One. 2018. doi: https://doi.org/10.1371/journal.pone.0208485

27. Asadifard F, Zeighami Mohammadi S, Bahrami Baba Heydari T. Sexual function of women with Chronic Renal Failure Undergoing Hemodialysis and factors related to it. Iran J Reprod Med. 2013;5(4):204–14

28. Peuranpaää P, Heliövaara-Peippo S, Fraser I, Paavonen J, Hurskainen R. Effects of anemia and iron deficiency on quality of life in women with heavy menstrual bleeding. Acta Obstet Gynecol Scand. 2014;93(7):654–60. doi: https://doi.org/10.1111/aogs.12394

29. Kennedy D, Koren G. Identifying women who might benefit from higher doses of folic acid in pregnancy. Can Fam Physician. 2012

30. MARS Protocol “Pregravid preparation”, 2023

31. Hanson MA, Bardsley A, De‐Regil LM, et al. The International Federation of Gynecology and Obstetrics (FIGO) recommendations on adolescent, preconception, and maternal nutrition: “Think Nutrition First”. Int J Gynecol Obstet. 2015;131(S4). doi: https://doi.org/10.1016/S0020-7292(15)30034-5

32. Resolution of the Council of Experts “Treatment and Prevention of Iron Deficiency Conditions at the Current Stage in the Context of Real Clinical Practice. The Place of Combined Iron Preparations in Combination with Folic Acid in the Treatment of Iron Deficiency Anemia and Iron Deficiency” // Obstetrics and Gynecology. — 2023. — No. 3. — pp. 155-162. doi: https://dx.doi.org/10.18565/aig.2023.3.155-162

33. Shikh E.V., Eremenko N.N., Pakhomova A.E., Pozdnyakov A.V. Compliance of the dissolution profile of Ferretab comp. with the requirements for modified release drugs: optimization of biopharmaceutical, pharmacokinetic and pharmacodynamic properties. // Pharmacology & Pharmacotherapy. — 2024. — No. 4

34. Gromova O.A., Torshin I.Yu. Micronutrients and reproductive health. — Manual-M: GEOTAR-Media, 2019

35. Torshin I.Yu. et al. Meta-analysis of clinical studies on the use of iron fumarate for the prevention and treatment of iron deficiency anemia in pregnant women. // Gynecology. — 2015. — V.17. — No.5. — P.24-31

36. Harrington M, et al. A comparison of the bioavailability of ferrous fumarate and ferrous sulfate in non-anemic Mexican women and children consuming a sweetened maize and milk drink. Eur J Clin Nutr. 2011;65(1):20-25. doi: https://doi.org/10.1038/ejcn.2010.185

37. Kumar A, et al. Drug-induced discoloration of teeth: an updated review. Clin Pediatr (Phila). 2012;51(2):181-185. doi: https://doi.org/10.1177/0009922811421000

38. Nordbö H, Eriksen HM, Rölla G, Attramadal A, Solheim H. Iron staining of the acquired enamel pellicle after exposure to tannic acid or chlorhexidine: preliminary report. Eur J Oral Sci. 1982;90(2):117-123. doi: https://doi.org/10.1111/j.1600-0722.1982.tb01533.x

39. Prskalo K, et al. Risk Factors Associated with Black Tooth Stain. Acta Clin Croat. 2017;56(1):28-35. doi: https://doi.org/10.20471/acc.2017.56.01.05

40. Christofides A, Asante KP, Schauer C, Sharieff W, OwusuAgyei S, Zlotkin S. Multi-micronutrient Sprinkles including a low dose of iron provided as microencapsulated ferrous fumarate improves haematologic indices in anaemic children: a randomized clinical trial. Matern Child Nutr. 2006;2(3):169-180. doi: https://doi.org/10.1111/j.1740-8709.2006.00060.x

41. Prilepskaya V.N. Treatment of iron deficiency conditions in women of reproductive age improves the course of pregnancy and perinatal outcomes and naturally reduces maternal mortality // Remedium. — 2021. — No. 1. — P. 33-35.


Review

For citations:


Andreeva E.N., Sheremetyeva E.V. Iron deficiency states in metabolically burdened women in the pregravid period. Bulletin of Reproductive Health. 2025;4(1):25-31. (In Russ.) https://doi.org/10.14341/brh12761

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ISSN 2075-6569 (Print)
ISSN 2310-421X (Online)