The All-Russian Expert Concilium about the influence of combined oral contraceptives on breast tissue took place in the 18^th of April 2024 in Moscow. It is necessary to study how to manage controlled risk factors of malign breast tumours. The influence of combined oral contraceptives on female breast tissue is widely discussed due to enlargement of possible estrogen components list. It is also actual to study if the combines oral contraceptives may act as potential enhancer/silencer for benign mammary dysplasia and breast cancer risk. The present article demonstrates. Consensus statement of the Russian society of obstetricians and gynecologists and the Russian association of mammologists on the effect of combined oral contraceptives on breast tissue.

Hyperandrogenism syndrome (HA) is a large group of endocrine diseases that occur due to various pathogenetic mechanisms, but are united by the principle of similar clinical symptoms due to excessive quantity and/or quality (activity) of male sex hormones in the female body. HA is one of the most common pathologies of the endocrine system in women of reproductive age. Patients with HA seek help from various specialists: cosmetic defects — to a cosmetologist, menstrual irregularities and infertility — to a gynecologist, pediatricians (congenital dysfunction of the adrenal cortex), therapists and endocrinologists  — remote consequences: dyslipidemia, arterial hypertension and carbohydrate metabolism disorders. Testosterone (T) occupies a key position in the hypothalamus-pituitary-gonads system. In women, it is synthesized by the adrenal cortex, ovarian cells, and is also formed in peripheral tissues. Russian clinical diagnostic laboratories have various diagnostic systems for determining all sorts of biochemical parameters and markers. The accuracy and correctness of the  determination depend on the availability of an adequate and accessible method, as well as the characteristics of the woman’s somatic status, for example, the presence of obesity. The emergence and development of modern technology of high-performance liquid chromatography with tandem mass spectrometric detection, which provides high productivity, almost 100% selectivity, the necessary sensitivity and reproducibility, allows using HPLC-MS/MS as a method recommended by clinical guidelines for diagnosing biochemical hyperandrogenism, which allows excluding false diagnoses in routine clinical practice.

This issue of reproductive medicine news presents current research and data from reviews and meta-analyses on the study and innovative methods of treating diseases of the reproductive system, presented in leading international periodicals.

The article presents the main prerequisites for the creation and the history of the development of the therapeutic and diagnostic department of assisted reproductive Research Centers of the Russian Federation of the Federal State Budgetary Institution «NMIC Endocrinology» of the Ministry of Health of Russia. The main tasks of this unit are the organization and provision of effective medical care for men and women with reproductive disorders, including against the background of endocrine diseases present. The specialists of the department apply a personalized approach to the management of a married couple from the moment of the beginning of the examination to the successful gestation.